One of the most helpful things I started doing in the drome was to focus on the order of monsters I kill more closely.
I always start with the highest damage dealing monsters, scissorions and hoodinons. These can combo me easily at higher rankings if i try to kill the other monsters first. After killing these, I will begin to focus on the next highest damage dealers, domestikons and mearadons. Finally I will focus on murmillions as they deal relatively inconsequential damage.
For imbuements, I would say vampirism and critical are a must as sometimes your hit can be the diference between dying and living. Waves with large numbers of scissiorions could benefit from earth and physical protection. Waves with hoodinons could benefit from fire/ice protection. Mearidons deal some large damage from their death beam, just avoid the beam. Also keep in mind to avoid kosheis amulet when facing domestikons as they can deal holy damage increased by kosheis amulet.
As a paladin, sometimes it is beneficial to start the wave in a corner and kill one creature before the others move around and see you. This can give you a slight advantage when the creatures are high damage dealers.