The easiest way to acumulate tomes, is to get the one you can find in the orc camp of zao with multiple characters:
Images taken from tibiawikia
If what you want to know is the best route to get all the different tomes, you will need to open 4 different quests:
- The new frontier quest
- Unnatural selection quest
- Uneasy alliance quest
- The new frontier quest
Route I would follow:
- Start doing The New Frontier Quest:
- Complete missions 1-3: When you are with NPC Lazaran start: Unnatural Selection Quest
- Do missions 1-5: Here you will get your 1st Tome of knowledge
- Keep doing missions 4-6 from the new frontier quest, with NPC Curos open An Uneasy Alliance Quest.
- Do mission 1 (unneasy aliance) and at the same time take your 2nd tome of knowledge which is in the orc camp where you are sent to (pictures of the emplacement above).
- Do mission 2 of the Unneasy Alliance Quest at the same time that you do Mission 7and 8 of The New Frontier Quest. You will get here your 3th and 4thTome of knowledge. >>>>> (Uneasy Ali.) (New Front).
- When you report the second mission of Unneasy Aliance Quest you will get the 5th tome of knowledge.
- Start mission Children of revolution quest with NPC Zalamon
- Keep doing The new frontier quest until mission 9. Up the the mountain there is a chest with the 6th tome of knowledge
- Do missions 1- 2 f revolution quest.While doing mission 2, take the 7th tome of knowledge:
- Do missions 3 and 4 of children of revolution quest. Here, when reporting you will get tome number 8th.
- In mission 5 of children of revolution quest, you will get the 9th tome of knowledge
- The next 2 tomes of knowledge can be found in different respawns after you deliver 8 tomes, for corruption hole, and 10 tomes of knowledge (for zao palace) to Cael:
- Last Tome of knowledge can be found upstairs the tower of Zzaion, where Zulazza the Corruptor Spawns, during its raid