No, it is not.
The only link between The Curse Spread Quest and Grimvale Quest, is the part where you need to 'active' the teleport to enter feroxa, but you don't even need to do this when feroxa is about to spawn, you can do this any day.
This is the room in grimvale that is used to active the teleport, you just need to move the tiles until they look like a 'V':
Image taken from tibialatina