Look in my opinion hotkeys are something really personal, that you need to set your HK the way it works better to you. But, I can give some advices the way I play.
I got all my attack hotkeys set near to each other, this way I use one hand only to attack.
Also, I set all my cure hotkeys near to each other to use the other hand only to cure myself (and to exeta res when it's needed)
And the others hk I set other things like equip/unequip items, summon, and other magics that I use but without the frequency of my hunting HK.
I can't tell if this is the best way to set your hotkeys, but it's the I ever hunted, so it's what work for me. My best advice is to follow something that you can handle easily and not missclick something.