I know that charms such as zap, freeze or enflame do not increase life and mana drained with activation. However, low blow does. Several new main charms have appeared with the winter update 2024:
- Carnage
- Overflux
- Overpower
- Savage Blow
Many players don't take into account that not every charm has drain synergy and therefore also increases survivability. List which main charms have synergy with drain imbues.