No, store items aren't destructible so it doesn't disappear when you use a disintegrate rune on them. When I used the rune it just did a poof on my cushion and the rune vanished. When I used this on some other items like Christmas presents from the store the rune didn't disappear. Please note store items can't be wrapped by anyone else besides the owner of the house and can't be transferred to another owner. I also tried to use this on a teleport scroll, gold converter, and store potions and it still didn't make them disappear. I know the disintegrate rune is only for movable objects and can work in a protection zone. Please note this rune won't work for items that are in your inventory, the item you want destroyed needs to be on the floor and movable.