<p>According to the <a rel="nofollow" href="https://www.tibia.com/forum/?action=announcement&announcementid=79&boardid=13#5e">technical FAQ:</a></p><blockquote><p><strong>5e) Is it allowed to use the extra buttons on a gaming mouse/keyboard as hotkeys?</strong></p><p>Yes, you can generally use the buttons of your gaming mouse or keyboard like hotkeys. However, please note that you may not bind more than one action to a button. For instance, it is acceptable to bind to a button the drinking of a mana potion. However, it would be illegal to assign to a button the drinking of a mana potion and then casting "exura". Thereby, it does not matter if the action is performed by pressing a combination of keys (e.g. CTRL+F1) or a single key (e.g. F1).</p></blockquote><p>So technically, it is allowed to use the scroll wheel to perform a single action. I think it's unlikely that someone would get deleted just for "spamming" a hotkey.</p><p>And obviously, macros that do automated things are not allowed (auto-heal, auto-loot, auto-equip, etc.).</p>etc.).</p><p><Edited></p><p>After reading Nightflyn's answer, I decided to contact customer support to ask specifically about binding a hotkey to the scroll wheel. Here's the answer:</p><blockquote><p>Yes, using the mouse scroll wheel to bind hotkeys to scroll up or down is allowed, as long as each scroll action (up, down or click) triggers only one in-game action per movement. This falls under the same rule that applies to other mouse buttons, ensuring that no automation or macro-like functionality is introduced.</p><p></p><p>If you need fhelp with anything else, feel free to ask!</p><p></p><p>Kind regards,</p><p>Manina</p><p>Tibia Customer Support</p></blockquote>